Plant recombinant erythropoietin attenuates inflammatory kidney cell injury
نویسندگان
چکیده
منابع مشابه
Recombinant human erythropoietin attenuates renal tubulointerstitial injury in murine adriamycin-induced nephropathy.
BACKGROUND Erythropoietin (EPO) has been found to provide cytoprotection against acute ischemic and toxic renal tubulointerstitial injury. This study aimed to elucidate the mechanism(s) underlying EPO protection while examining whether EPO provides tubulointerstitial protection in a mouse model with adriamycin (ADR)-induced tubulointerstitial injury. METHODS Adriamycin nephropathy (AN) was in...
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Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence, however, suggests that EPO has additional organ protective effects, which may be useful in the prevention or treatment of acute kidney injury. These protective mechanisms are multifactor...
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Erythropoietin (EPO) has traditionally been viewed as a hormone dedicated to the regulation of erythropoiesis. More recently, the EPO receptor (EPOR) has been found to be expressed in a large variety of non-haematopoietic tissues suggesting that EPO might have important actions beyond erythrocyte production. Over the last five years, short-term, high dose administration of EPO has been shown to...
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ژورنال
عنوان ژورنال: Plant Biotechnology Journal
سال: 2009
ISSN: 1467-7644,1467-7652
DOI: 10.1111/j.1467-7652.2008.00389.x